Endocrine Abstracts

Introduction: Adrenal metastases used to be rare in endocrinology compared to others adrenal tumours, and deemed to have a dire prognosis. Our aim is to analyze 13 cases in order to study their morphological aspects, their causes, and their outcome.Subjects and method: Thirteen cases were studied over a long period of time (2000–2012). All of them had biological, hormonal, and radiological assessments.Results: We had ten men a...

Introduction: Congenital trans-sphenoidal meningocele (TM) is a rare clinical entity. It can be traumatic, congenital or from tumour origin. It results from a defect in the sphenoid bone ontogenesis. In its classical form, the TM is revealed in adults, frequently in women in the fourth or fifth decade by rhinorrhea or cerebrospinal fluid leak through a bony defect in the sphenoid floor. Our aim is to report a case of large TM without rhinorrhea, and as a part of midline abnorm...

Several observations brought reported a big frequency (12–50%) of pituitary insufficiency and abnormalities of the median line. The endocrine disorders are hypothamic origin and come along of pituitary ontogeny in more 30% of the cases. These abnormalities are associated with a defect of the embryological development of the bird nasofrontal which allows the development of various regions of the encephalon and the face. We report the observations of two boys KY 18 years ol...

Introduction: Compared to secondary amenorrhea, primary amenorrhea is deemed to be a rare condition. Our aim is to study its annual frequency during a long period of time, and to analyze its different aetiologies in an Endocrine Department.Methods: All patients referred for primary amenorrhea between 1980 and 2012 were studied. We took in account personal and family history, clinical examination, hormonal, cytogenetic and immunological assessments, and r...

Introduction: In medical practice ambiguous genitalia is a relatively are condition. The combination of two causes in genital malformation is exceptional. Our aim is to describe a person having an abnormal karyotype with a chimerism (46,XY/46,XX) and a deficit in 17β-hydroxysteroid dehydrogenase 3 (17β-HSD): an enzyme in the testes that transforms D4 Androstenedione to testosterone and androstenedione to dihydro testosterone or DHT.Case report:...

Introduction: Generously supported by IPSEN)-->Epilepsy is a heterogeneous condition with different aetiologies including genetics, cerebral trauma, toxic exposures, infection, vascular diseases and neoplasms. Among the last ones, pituitary tumours (PT) are rarely responsible of convulsions, except when they are very large invading the nervous system. Our aim is to analyze the conditions under which the epilepsy appears and disappear...

Introduction: Metastases of thyroid carcinoma to the choroid and/or orbit are rare and usually occur at an advanced stage of the disease. The principal symptoms are decreased or blurred vision and/or persistent eye pain but they can be totally asymptomatic. They are diagnosed by ultrasound ocular CT and/or MRI scanning. The diagnosis is certain if they fix radioactive iodine. Their prognosis is very bad. Enucleation is the treatment of choice in cases of visual impairment. We ...

Dilated cardiomyopathy with congestive heart failure (CHF) is a very rare complication of growth hormone excess due to (GH)-secreting pituitary adenoma; It occurs in nearly 3% of acromegaly. Our aim was to report a case with CHF, large right auricular thrombus, and pulmonary embolism.Case report: A man aged 41, was known as an acromegaly gigantism due to a large pituitary somatotroph adenoma. That one was operated on twice but the tumor persisted and GH=...

Pheochromocytomas and paragangliomas are rare but life threatening tumors secreting catecholamines. They could be either sporadic or inherited. Either isolated or integrated in genetic syndromes such as Von Hippel Lindau (VHL) (OMIM193300) which is an autosomal dominant disorder resulting from germline mutations in the VHL gene.Observation: We report a 42-year-old man operated at 8 years old for bilateral pheochromocytoma revealed by adrenergic symptoms ...

Introduction: Cortisol has numerous actions on glucose metabolism and insulin action which explain the frequency of glucose abnormalities in Cushing’s syndrome (CS). The aim of our work was to assess the prevalence and characteristics of diabetes in CS.Material and methods: This is a retrospective study concerning 51 CS (44F/7M) in whom we looked for the presence of diabetes either by fasting glycaemia or 75 g oral glucose tolerance test. Thereafter...